While the myriad changes that occur with immunosenescence are complex and not fully understood, in relation to AD/ADRD, a key dysfunction is impaired chemotaxis (cell movement in response to a chemical stimulus) and phagocytic function of microglia in the brain and peripheral macrophages (Liu et al., 2023
It does this by stimulating insulin secretion and reducing the amount of sugar released by the liver
Similarly, dietary interventions such as ketogenic and fasting-mimicking diets show metabolic and immunologic benefits in mice, but their applicability and sustainability in human patients warrant rigorous clinical assessment
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For GC/MS analysis, samples were derived using bistrimethyl-silyl-triflouroacetamide (BSTFA), and analysed on a Thermo-Finnigan Trace DSQ fast-scanning single-quadrupole mass spectrometer using electron impact ionisation
